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Weightloss calcium supplements, magnesium, and you can phosphorus consumption and chance of heart attack in the Chinese adults

Weightloss calcium supplements, magnesium, and you can phosphorus consumption and chance of heart attack in the Chinese adults

Controversial results have been reported about the association of calcium, magnesium, and phosphorus and stroke risk, but none in China. To investigate the association between dietary calcium, magnesium, phosphorus, and stroke incidence in Chinese adults, we collected data from the China Health and Nutrition Survey (CHNS) from 2004 to 2011, including 6411 participants aged 45–79 years and free of stroke at baseline. Diet was assessed by interviews combining 3-d 24-h food recalls and household food inventory weighing at each survey round. The stroke incident was identified based on the validated self-report. Multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). For 32,024 person-years of follow-up, 179 stroke cases were documented. After adjustment for major lifestyle and dietary risk factors, calcium intake was positively associated with reduced stroke risk, and the HR of stroke comparing extreme quartiles was 0.53 (95% CI 0.29–0.96, Pdevelopment = 0.03). In further stratified analyses, significant heterogeneity across sex strata was found (Pcorrespondence = 0.03). Dietary calcium intake among men was more inversely related to stroke, with HRs being 0.33 (95% CI 0.15–0.76, P trend = 0.02), compared to 1.24 (95% CI 0.46–3.35, Ptrend = 0.89) among women. However, no significant association between stroke and magnesium or phosphorus was revealed. Our findings suggest that higher dietary calcium intake was associated with a lower risk of stroke in Chinese adults, particularly in men.


As an excellent cerebrovascular disease, coronary attack is probably the top reason behind death for the setup and you may development regions. Good ten% full yearly death worldwide try estimated are attributable so you’re able to it 1 . Probably the coronary arrest survivors, just as much as fifteen–30% is permanently handicapped dos , which leads to just as much as 113 mil impairment-adjusted lifetime ages shed 3 . Asia has got the highest projected lives danger of heart attack all over the world (39.3%) with regards to the 2016 in the world weight out of condition (GBD) local study 4 . Frequently, stroke has been a life threatening social health issue to own China into the up against the increased ageing population. lumen online Therefore, pinpointing the fresh modifiable exposure affairs try clicking into cures and you may the improvement from existence quality of stroke patients therefore the reduction of big socio-economic weight.

Fat reduction calcium supplements, magnesium, and you may phosphorus intakes and threat of heart attack into the Chinese adults

Even though the particular etiology isn’t completely elucidated, coronary attack could be thought an illness pertaining to genetic and you can environment chance facts (specifically weight loss) or even the interplay of them products. Detailed proof suggests that weight loss adjustment are beneficial to cease the onset of stroke 5,six,eight . A close dating can be obtained ranging from calcium supplements, magnesium, phosphorus, and you can vascular security, which happen to be considered very important wellness effects getting vascular infection simply because they is also control vascular calcification and you may endothelial malfunction 8,9 . To date, several research has looked at the partnership between these types of nourishment consumption and you will stroke exposure ten,eleven,twelve , however the results are contradictory. Like, browse in the European inhabitants shown magnesium intake, although not calcium try notably connected with a reduced danger of heart attack eleven . Alternatively, in the us, calcium supplements consumption, in the place of magnesium, leads to ong guys, magnesium consumption are inversely associated with coronary attack twelve . Furthermore, each one of these reports was indeed conducted for the west populations with high intakes of those nutrients thirteen,14 . Although not, to our studies, absolutely nothing known about the connection of weightloss calcium supplements, magnesium, and you may phosphorus consumption having stroke occurrence on Chinese inhabitants. The average weight-loss intake ones micronutrients certainly one of Chinese some body sipping mainly plant-based diet is actually considered below that Europeans and Us citizens that a great deal more whole milk and you will meats situations fifteen . In this context, a massive-measure possible studies about Chinese population to help you enhance new association’s facts is actually undoubtedly requisite. I, therefore, made use of research on the China Health and Diet Survey (CHNS) to evaluate the connection anywhere between weight-loss calcium supplements, magnesium, and you can phosphorus intakes and you may further occurrence away from stroke in the Chinese grownups.